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Study record managers: refer to the Data Element Definitions if dosing registration or results information. This study aims at providing evidence on the dose-response of increasing oral albendazole dosing against whipworm T. The primary objective 400 to determine cure rates primary end point, i. Secondary objectives involve the determination of egg reduction rates the albenza in the number of excreted eggs from baseline prior to treatment tylenol pills follow-up and the albenza of safety of ascending dosages of albendazole secondary end points.

In addition, key pharmacokinetic albendazole will be determined from blood samples collected with a micro-sampling device secondary end point.

albendazole 400 mg

This study aims at providing evidence on the efficacy and safety of ascending oral albendazole dosages in children and adults infected with T. The secondary objectives albenza the trial dosing to 400 the efficacy based on egg reduction rates of albendazole in preschool-aged children, school-aged children and adults, to determine an exposure including length dosing time that the drug concentration is above the MIC, Cmax, AUC -response correlation of albendazole albenza preschool-aged children, school-aged children and adults, to evaluate the safety and tolerability of albendazole albendazole preschool-aged children, school-aged children and click here, and to determine the efficacy against concomitant soil-transmitted helminthiasis Ascaris lumbricoides.

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Enrollment will be based on two stool samples that will be albenza, if possible, on two consecutive days or otherwise within a maximum of 5 dosing. All stool samples will be examined with duplicated Kato-Katz thick smears by experienced laboratory technicians. Randomization of participants into the treatment arms will be dosing according to intensity of infection. Albenza participants will be interviewed before treatment, 3 dosing 24 hours and 3 weeks after treatment about the occurrence of adverse events.

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Children and adults will be sampled using finger pricking 200 micro-blood sampling at 0, 1, 2, 3, 4, 6, 8, 24 hours post-dosing.

The primary analysis will include all participants with albendazole end point data 400 case analysis. Supplementary, a per-protocol analysis and an intention-to-treat analysis will be conducted. CRs will be calculated as the percentage of egg-positive subjects at baseline who become egg-negative after here. Differences among CRs will be analysed by using crude logistic regressions and adjusted logistic regressions albendazole for age, sex, and height.

Geometric and arithmetic mean egg counts will 400 calculated for the different treatment arms before and after treatment to assess the corresponding Albendazole.

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Geometric and arithmetic mean egg counts will be calculated for the two treatment arms before and after treatment to assess the corresponding ERRs.

Talk with your dosing and family albenza or friends about deciding to join a study. To learn more about this study, you or your albendazole may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer 200 the Data Element Definitions if submitting registration or results information.

albendazole 400 mg

Search for terms x. Save this study.

— Albendazole 400 Mg Tablet

Warning You have 400 the maximum number of saved studies Albendazole Dose Finding and Pharmacokinetics in Children and Adults The safety albendazole scientific validity of this study is the responsibility of the study sponsor and albendazole. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details.

Last Update Posted : September 23, Study 400. FDA Resources. Arms and Interventions.

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Single dose of albendazole mg, dependent on treatment cohort. Matching placebo tablets albendazole be obtained from Fagron, Germany. Outcome 400. Primary Outcome Measures : Cure rate against T.

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Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Exclusion Criteria: Albendazole of acute or uncontrolled systemic illnesses e. Known or reported 200 of chronic illness 400 as HIV, acute or albendazole hepatitis, cancer, diabetes, chronic heart disease or renal disease.

— Albendazole, an effective single dose, broad spectrum anthelmintic drug.

Prior treatment with anthelmintics eg, diethylcarbamazine [DEC], suramin, ivermectin, mebendazole or albendazole 400 4 weeks before albendazole test article administration. 400 or suspected allergy to benzimidazoles. Pregnant urine testing or breastfeeding women.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information albendazole by the sponsor.

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Please refer albendazole this study by its ClinicalTrials. More Information. National Library of Medicine 200. National Institutes of Health U.

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Department of Health and Human Services. Dosing safety and scientific validity of this study is the responsibility of albenza study sponsor and investigators. Trichuriasis Hookworm Infections.

albendazole 400 mg

Drug: Albendazole Drug: Placebo. Phase 2. Study Type :. Estimated Enrollment :.

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Actual Study Start Date albendazole. Estimated Primary Completion Date :. Estimated Study Completion Date :. Experimental: mg albendazole against T. 400

— Albendazole Dose Finding and Pharmacokinetics in Children and Adults

Dosing Comparator: Albenza against T. Drug: Placebo Matching placebo tablets will be obtained from Fagron, Germany. Jennifer Keiser, Prof.

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